BIFUNCTIONAL CHIRAL AUXILIARIES .4. ALKYLATION OF ENOLATES DERIVED FROM 1,3-DIACYL-TRANS-4,5-TETRAMETHYLENEIMIDAZOLIDIN-2-ONES

被引：18

作者：

DAVIES, SG

MORTLOCK, AA

机构：

[1] The Dyson Perrins Laboratory, Oxford, OX1 3QY, South Parks Road

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(00)91875-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Addition of alkyl halides to sodium and potassium enolates of 1,3-diacyl-trans-4,5-tetramethyleneimidazolidin-2-ones allows diastereoselective alkylation of both acyl sidechains with the latter enolates showing generally higher stereoselectivities. S-(-)-3-Phenyl-2-methylpropan-1-ol 6 was prepared in this way with a 93% enantiomeric excess.

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页码：1117 / 1120

页数：4

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