CORRECTION OF NEUTROPHIL CHEMOTAXIS DEFECT IN PATIENTS WITH GAUCHER DISEASE BY LOW-DOSE ENZYME REPLACEMENT THERAPY

被引：26

作者：

ZIMRAN, A

ABRAHAMOV, A

AKER, M

MATZNER, Y

机构：

[1] HADASSAH UNIV HOSP, HEMATOL UNIT, JERUSALEM, ISRAEL

[2] HADASSAH UNIV HOSP, SHAARE ZEDEK MED CTR, GAUCHER CLIN, JERUSALEM, ISRAEL

[3] HADASSAH UNIV HOSP, DEPT PEDIAT, JERUSALEM, ISRAEL

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1993年 / 43卷 / 01期

关键词：

CEREDASE; INFECTION; GLUCOCEREBROSIDASE;

D O I：

10.1002/ajh.2830430118

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have recently described a chemotactic defect in severely afflicted Gaucher disease patients. Two of the patients were treated with low-dose intravenous enzyme replacement (Ceredase). Marked improvement in their hematological status, organomegaly, and growth was observed. In addition, their chemotactic defect and their tendency towards infections were corrected within 1 year of treatment.

引用

页码：69 / 71

页数：3

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