ONTOGENY OF RENIN AND AT1 RECEPTOR IN THE RAT

被引：36

作者：

GOMEZ, RA

TUFROMCREDDIE, A

EVERETT, AD

PENTZ, ES

机构：

[1] Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, 22908, VA, MR4 Building

来源：

PEDIATRIC NEPHROLOGY | 1993年 / 7卷 / 05期

关键词：

KIDNEY DEVELOPMENT; RENIN-ANGIOTENSIN SYSTEM; IN-SITU HYBRIDIZATION; MESSENGER RIBONUCLEIC ACID;

D O I：

10.1007/BF00852571

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The enzyme renin and the angiotensin II (Ang II), subtype I receptor (ATI) are developmentally regulated in a tissue-specific manner. In early life, renin is expressed widely along the renal vasculature. As maturation progresses, there is a decrease in renin mRNA levels and a shift in the localization of renin close to the glomerulus. In addition, in the newborn rat, the number of renin-secreting cells is higher than in the adult rat. Exposure of neonatal and adult cells to Ang II results in a decrease of similar magnitude in the number of renin-secreting cells. These findings suggest that the high levels of renin observed in immature animals are due to increased renin synthesis and release rather than to a blunted response to Ang II. Expression of the ATI gene is also developmentally regulated in a tissue-specific manner. With maturation, ATI mRNA levels decrease in the kidney while they increase in the liver. The localization of ATI transcripts in precursor cells of the nephrogenic cortex suggests a role for this receptor in nephron growth and development. Inhibition of ATI with DUP753 results in delayed kidney and somatic growth and in increased renin mRNA levels and recruitment of renin-containing cells. These observations suggest that Ang II exerts a tonic negative feedback on renin gene expression via the ATI receptor subtype. Further studies are necessary to delineate the molecular and cellular signals mediating these developmental changes.

引用

页码：635 / 638

页数：4

共 28 条

[1]

David J.O., Freeman R.H., Mechanisms regulating renin release, Physiol Rev, 56, pp. 1-56, (1976)

[2]

Keeton T.K., Campbell W.B., The pharmacological alteration of renin release, Pharmacol Rev, 32, pp. 81-227, (1980)

[3]

Bumpus F.M., Catt K.J., Chiu A.T., DeGaspara M., Goodfriend T., Husain A., Peach M.J., Taylor D.G., Timmermans P.B.M.W.M., Nomenclature for angiotensin receptors. A report of the Nomenclature Committee of the Council for High Blood Pressure Research, Hypertension, 17, pp. 720-721, (1991)

[4]

Ferrario C.M., Brosnihan K.B., Diz D.I., Jaiswal N., Khosla M.C., Milsted A., Tallant E.A., Angiotensin-(1–7): a new hormone of the angiotensin system, Hypertension, 18, pp. 126-133, (1991)

[5]

Jaiswal N., Diz D.I., Chappell M.C., Khosla M.C., Ferrario C.M., Stimulation of endothelial cell prostaglandin production by angiotensin peptides: characterization of receptors, Hypertension, 19, pp. 49-55, (1992)

[6]

Ichikawa I., Harris R.C., Angiotensin actions in the kidney: renewed insight into the old hormone, Kidney Int, 40, pp. 583-596, (1991)

[7]

Norman J.T., The role of angiotensin II in renal growth, Renal Physiol Biochem, 14, pp. 175-185, (1991)

[8]

Ray P.E., Aguilera G., Kopp J.B., Horkoshi S., Klotman P.E., Angiotensin II receptor-mediated proliferation of cultured human fetal mesangial cells, Kidney Int, 40, pp. 764-771, (1991)

[9]

Gomez R.A., Chevalier R.L., Sturgill B.C., Johns D.W., Peach M.J., Carey R.M., Maturation of the intrarenal renin distribution in Wistar-Kyoto rats, J Hypertens, 4, pp. S31-S33, (1986)

[10]

Pupilli C., Gomez R.A., Tuttle J.B., Peach M.J., Carey R.M., Spatial association of renin-containing cells and nerve fibers in developing rat kidney, Pediatr Nephrol, 5, pp. 690-695, (1991)

← 1 2 3 →