MANIPULATION OF THE ALDOL ADDUCTS FROM LACTATE-DERIVED KETONES - A VERSATILE CHIRAL AUXILIARY FOR THE ASYMMETRIC-SYNTHESIS OF BETA-HYDROXY CARBONYL-COMPOUNDS

被引：58

作者：

PATERSON, I

WALLACE, DJ

机构：

[1] University Chemical Laboratory, Cambridge, CB2 1EW, Lensfield Road

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 48期

关键词：

D O I：

10.1016/0040-4039(94)88435-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The ketones 1 and 2 can be transformed into a wide range of enantiomerically-pure anti and syn alpha-methyl-beta-hydroxy ketones and aldehydes. The alpha'-methyl group in 5 and 11 may be retained, demonstrating the use of the lactate-derived group as an optional chiral auxiliary.

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页码：9087 / 9090

页数：4

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