DEMONSTRATION OF DERIVATION OF RAT URINARY BRADYKININ FROM PLASMA LOW-MOLECULAR-WEIGHT KININOGEN - A STUDY USING KININOGEN-DEFICIENT RATS

被引：10

作者：

HAGIWARA, Y ^{[1
]}

KOJIMA, M ^{[1
]}

HAYASHI, I ^{[1
]}

OHISHI, S ^{[1
]}

机构：

[1] KITASATO UNIV,SCH PHARMACEUT SCI,DEPT PHARMACOL,MINATO KU,TOKYO 108,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 204卷 / 03期

关键词：

D O I：

10.1006/bbrc.1994.2593

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The origin of urinary bradykinin was defined by use of plasma kininogen deficient B/N-Katholiek rats, whose ureter urine contains very low amount of urinary kinin. The kinin level increased after the rats received an infusion of normal plasma. Furthermore, the bradykinin content in the ureter urine of these kininogen-deficient rats increased more by infusion of partially purified rat low-molecular-weight kininogen than by that of high-molecular-weight kininogen. Urinary kallikrein activity of B/N-Katholiek rats was enzymatically identical with that of normal B/N-Kitasato rats. These results indicate that urinary bradykinin found in the ureter urine of normal rats is derived from plasma low-molecular-weight kininogen by cleavage by urinary kallikrein. (C) 1994 Academic Press, Inc.

引用

页码：1219 / 1224

页数：6

共 17 条

[1]

EISEN V, 1970, HDB EXPERIMENTAL PHA, V25, P82

[2]

HAGIWARA Y, 1993, JAPAN J PHARM S292P, V61

[3] DEMONSTRATION OF THE 3RD KININOGEN IN HIGH AND LOW-MOLECULAR WEIGHT KININOGENS-DEFICIENT BROWN NORWAY KATHOLIEK RAT [J].

HAYASHI, I ;

INO, T ;

KATO, H ;

IWANAGA, S ;

NAKANO, T ;

OHISHI, S .

THROMBOSIS RESEARCH, 1984, 36 (06) :509-516

[4]

HAYASHI I, 1985, J BIOL CHEM, V260, P6115

[5] ORIGIN AND CONTENT OF METHIONYL-LYSYL-BRADYKININ, LYSYL-BRADYKININ AND BRADYKININ IN HUMAN URINE [J].

HIAL, V ;

KEISER, HR ;

PISANO, JJ .

BIOCHEMICAL PHARMACOLOGY, 1976, 25 (22) :2499-2503

[6]

KATO H, 1981, METHOD ENZYMOL, V80, P172

[7]

KATO H, 1976, KININS PHARMACODYNAM, P135

[8]

MARGOLIUS HS, 1971, LANCET, V2, P1063

[9]

MILLS IH, 1976, FED PROC, V35, P181

[10] NEW FLUOROGENIC SUBSTRATES FOR ALPHA-THROMBIN, FACTOR-XA, KALLIKREINS, AND UROKINASE [J].

MORITA, T ;

KATO, H ;

IWANAGA, S ;

TAKADA, K ;

KIMURA, T ;

SAKAKIBARA, S .

JOURNAL OF BIOCHEMISTRY, 1977, 82 (05) :1495-1498

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