MOLECULAR-CLONING OF M6 - IDENTIFICATION OF A PLP/DM20 GENE FAMILY

被引：137

作者：

YAN, YM ^{[1
]}

LAGENAUR, C ^{[1
]}

NARAYANAN, V ^{[1
]}

机构：

[1] CHILDRENS HOSP, DEPT PEDIAT, PITTSBURGH, PA 15261 USA

来源：

NEURON | 1993年 / 11卷 / 03期

关键词：

D O I：

10.1016/0896-6273(93)90147-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

M6 is a membrane glycoprotein that is expressed on central neurons and certain polarized epithelia from early developmental stage. Antibodies against M6 interfere with cerebellar neurite outgrowth in vitro. Two closely related cDNAs were obtained by expression cloning, both of which showed high homology with the major CNS myelin protein PLP/DM20. Although M6 and PLP/DM20 share many molecular characteristics, in situ hybridization revealed nonoverlapping distributions of their mRNAs in mouse CNS. The identification of a gene family including neuron-specific M6 and glia-specific PLP/DM20 in CNS suggests a broader functional role for these molecules than myelination.

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页码：423 / 431

页数：9

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