HIV-ASSOCIATED LYMPHOMA OF THE GASTROINTESTINAL-TRACT - THE UNIVERSITY-OF-TORONTO AIDS-LYMPHOMA STUDY-GROUP EXPERIENCE

被引：17

作者：

IMRIE, KR ^{[1
]}

SAWKA, CA ^{[1
]}

KUTAS, G ^{[1
]}

BRANDWEIN, J ^{[1
]}

WARNER, E ^{[1
]}

BURKES, R ^{[1
]}

QUIRT, I ^{[1
]}

MCGEER, A ^{[1
]}

SHEPHERD, FA ^{[1
]}

机构：

[1] TORONTO HOSP,DIV GEN,DEPT MED,TORONTO,ON M5G 2C4,CANADA

来源：

LEUKEMIA & LYMPHOMA | 1995年 / 16卷 / 3-4期

关键词：

NON-HODGKINS LYMPHOMA; AIDS; GASTROINTESTINAL LYMPHOMA;

D O I：

10.3109/10428199509049774

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We present a retrospective analysis of 31 (30 male) patients with HIV-associated gastrointestinal lymphoma which was undertaken to determine the natural history and response to therapy. Only seven patients had stage I or II lymphoma and 22 had stage IV. Pathology included diffuse large cell(13), immunoblastic (10), and small cell non-cleaved (7). The median age at presentation was 39 years (range 24-59), and the median CD4 count before treatment was 100/mu L (range 4-1150). Eighty-seven percent of patients received systemic chemotherapy and significant response was seen in 84% (CR 38%; PR 46%). Hematologic toxicity was high (febrile neutropenia in 44% and dose reductions were required in 81%) and perforation occurred in five patients. Median survival for all patients was 6 months and death was secondary to lymphoma in 61%, treatment toxicity in 10%, other AIDS-related illnesses in 25% and other causes in 4%. Survival was shorter for patients with bone marrow involvement and for those with poor performance status. HIV-associated GI lymphoma has a poor prognosis despite good initial response to chemotherapy and is associated with a higher perforation rate than in HIV negative patients.

引用

页码：343 / 349

页数：7

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