DEPENDENCE OF DV/DT AND DP/DT OF VENTRICULAR PRESSURE FROM SYSTOLIC MECHANICAL RESULT OF LEFT HEART VENTRICLE

Experiments were performed at isolated cat hearts to examine correlations between dp/dtmax or dv/dtmax of the ventricular pressure curve and stroke volume, cardiac index, 1/2 mv2 and performance of the left ventricle. By metabolic alcalosis, pressure load and increased preload the dynamics of ventricular contraction and its physical result were varied. Each heart showed an exact correlation between dv/dtmax and the physical work of the left chamber per systole, respectively performance. Controversely, there could not be found correlations between dv/dtmax and stroke volume, cardiac index and 1/2 mv2. By separate examination of these correlations at metabolic alcalosis, pressure load or increased preload, there exists a particular dependence of dv/dtmax from these parameters. However, the dependence of dv/dtmax from left ventricular work per systole is unchanged. Similar correlations were found between dp/dtmax and the left ventricular work per systole. It is concluded that there exists a proportionality between dv/dtmax as the most important derivation of the ventricular pressure curve and the physical result of ventricular contraction. © 1969 Springer-Verlag.