NUCLEOTIDE-SEQUENCE ANALYSES OF THE GENES ENCODING THE HN, M, NP, P, AND L PROTEINS OF 2 HOST RANGE MUTANTS OF SENDAI VIRUS

被引：21

作者：

MIDDLETON, Y

TASHIRO, M

THAI, T

OH, J

SEYMOUR, J

PRITZER, E

KLENK, HD

ROTT, R

SETO, JT

机构：

[1] CALIF STATE UNIV LOS ANGELES, DEPT MICROBIOL, LOS ANGELES, CA 90032 USA

[2] JICHI MED SCH, DEPT VIROL, MINAMI KAWACHI, TOCHIGI 32904, JAPAN

[3] UNIV MARBURG, INST VIROL, W-3550 MARBURG, GERMANY

[4] UNIV GIESSEN, INST VIROL, W-6300 GIESSEN, GERMANY

来源：

VIROLOGY | 1990年 / 176卷 / 02期

关键词：

D O I：

10.1016/0042-6822(90)90040-X

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Comparative nucleotide sequence analyses of the genome of Sendai virus (strain Z) and two host range mutants, ts-f1 and F1-R, previously described revealed that the is defect of ts-f1 can be attributed to two nucleotide exchanges in the NP gene. These exchanges lead to a single amino acid substitution. A single base pair change was found in both the P and L genes of F1-R, but not of ts-f1. Both host range mutants have the two same exchanges in the M gene. These additional mutations are discussed concerning their significance in the pantropic properties of the host range mutants. © 1990.

引用

页码：656 / 657

页数：2

共 13 条

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