CHRONIC EFFECTS OF SYNTHETIC ENDOTHELIN ON BLOOD-PRESSURE AND SODIUM-EXCRETION IN RATS

被引:13
作者
YASUJIMA, M
ABE, K
KANAZAWA, M
YOSHIDA, K
SATO, M
TAKEUCHI, K
TSUNODA, K
KUDO, K
KOHZUKI, M
OMATA, K
YOSHINAGA, K
机构
[1] Department of Internal Medicine, Tohoku University School of Medicine, Sendai
[2] Department of Clinical Biology, Hormonal Regulation, Tohoku University School of Medicine, Sendai
关键词
Blood pressure regulation; Calcium channel blockers; Conscious rats; Endothelin;
D O I
10.1093/ajh/3.8.635
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Continuous infusion of endothelin at a rate of 60 μg/kg/day into the jugular vein of rats via osmotic minipumps induced a significant increase in systolic blood pressure, but did not induce any significant changes in urine volume and urinary sodium excretion, compared to those in vehicle-infused rats. When 6 mg/kg/day of benidipine, a newly developed calcium channel blocker, was administered simultaneously with 60 μg/kg/day of endothelin, the systolic blood pressure of conscious rats rose on Day 1 to only 137.0 ± 2.4 mm Hg (P <.05) compared to the rise to 163.8 ± 4.7 mm Hg when endothelin alone was infused. The antihypertensive effect of benidipine was sustained. The present results suggest that endothelin can act as a circulating hormone. In addition, they clearly demonstrate that the calcium channel blocker attenuates the elevation of blood pressure induced by endothelin. © 1990 by the American Journal of Hypertension, Ltd.
引用
收藏
页码:635 / 637
页数:3
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