EFFECT OF UNILATERAL PERINATAL HYPOXIC-ISCHEMIC BRAIN INJURY ON STRIATAL DOPAMINE UPTAKE SITES AND D1 AND D2 RECEPTORS IN ADULT-RATS

被引：26

作者：

KOSTIC, VS ^{[1
]}

PRZEDBORSKI, S ^{[1
]}

JACKSONLEWIS, V ^{[1
]}

CADET, JL ^{[1
]}

BURKE, RE ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,INST NEUROL,DEPT NEUROL,BLACK BLDG,RM 302,630 W 168TH ST,NEW YORK,NY 10032

来源：

NEUROSCIENCE LETTERS | 1991年 / 129卷 / 02期

关键词：

HYPOXIA-ISCHEMIA; STRIATUM; BINDING AUTORADIOGRAPHY; H-3]SCH-23390; H-3]SPIPERONE; H-3]MAZINDOL;

D O I：

10.1016/0304-3940(91)90460-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of unilateral perinatal hypoxic-ischemic brain injury on striatal dopamine uptake sites and on D1 and D2 receptors was investigated in rat by using in vitro quantitative receptor binding autoradiography, 9-11 weeks after the insult. Saturation experiments revealed a significant 20% decrease in maximal binding capacity (B(max)) for [H-3]spiperone-labeled D2 receptors on the side of the lesion in comparison to the non-lesioned contralateral side or to either side of control animals. There was no significant change in [H-3]mazindol-labeled dopamine uptake sites or in [H-3]SCH 23390-labeled D1 receptor characteristics (B(max) and K(d)) on the lesioned side. We conclude that the decrease in D2 receptor binding previously observed in immature animals is persistent, whereas the decrease in D1 binding is not.

引用

页码：197 / 200

页数：4

共 17 条

[1] D-1 DOPAMINE RECEPTOR CHANGES AFTER STRIATAL QUINOLINIC ACID LESION [J].

BARONE, P ;

TUCCI, I ;

PARASHOS, SA ;

CHASE, TN .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 138 (01) :141-145

[2] UNILATERAL HYPOXIC-ISCHEMIC INJURY IN NEONATAL RAT RESULTS IN A PERSISTENT INCREASE IN THE DENSITY OF STRIATAL TYROSINE-HYDROXYLASE IMMUNOPEROXIDASE STAINING [J].

BURKE, RE ;

KENT, J ;

KENYON, N ;

KARANAS, A .

DEVELOPMENTAL BRAIN RESEARCH, 1991, 58 (02) :171-179

[3] QUANTITATIVE MORPHOLOGICAL ANALYSIS OF STRIATAL CHOLINERGIC NEURONS IN PERINATAL ASPHYXIA [J].

BURKE, RE ;

KARANAS, AL .

ANNALS OF NEUROLOGY, 1990, 27 (01) :81-88

[4]

Coyle J T, 1977, Int Rev Neurobiol, V20, P65, DOI 10.1016/S0074-7742(08)60651-0

[5] D-1 DOPAMINE-RECEPTORS IN THE RAT-BRAIN - AUTORADIOGRAPHIC LOCALIZATION USING [H-3]SCH 23390 [J].

DAWSON, TM ;

GEHLERT, DR ;

YAMAMURA, HI ;

BARNETT, A ;

WAMSLEY, JK .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 108 (03) :323-325

[6] SELECTIVE CORTICAL INFARCTION REDUCES [H-3]SULPIRIDE BINDING IN RAT CAUDATE-PUTAMEN - AUTORADIOGRAPHIC EVIDENCE FOR PRESYNAPTIC D2 RECEPTORS ON CORTICOSTRIATE TERMINALS [J].

FILLOUX, F ;

LIU, TH ;

HSU, CY ;

HUNT, MA ;

WAMSLEY, JK .

SYNAPSE, 1988, 2 (05) :521-531

[7]

JAVITCH JA, 1985, J NEUROSCI, V5, P1513

[8] NEUROTRANSMITTER ALTERATIONS IN A MODEL OF PERINATAL HYPOXIC-ISCHEMIC BRAIN INJURY [J].

JOHNSTON, MV .

ANNALS OF NEUROLOGY, 1983, 13 (05) :511-518

[9] QUANTITATIVE AUTORADIOGRAPHY OF DOPAMINE-D2 SITES IN RAT CAUDATE-PUTAMEN - LOCALIZATION TO INTRINSIC NEURONS AND NOT TO NEOCORTICAL AFFERENTS [J].

JOYCE, JN ;

MARSHALL, JF .

NEUROSCIENCE, 1987, 20 (03) :773-795

[10] MULTIPLE RECEPTORS FOR DOPAMINE [J].

KEBABIAN, JW ;

CALNE, DB .

NATURE, 1979, 277 (5692) :93-96

← 1 2 →