EFFECT OF CHLOROFORM INGESTION ON THE GROWTH OF SOME MURINE TUMORS

被引:8
作者
CAPEL, ID
DORRELL, HM
JENNER, M
PINNOCK, MH
WILLIAMS, DC
机构
[1] The Marie Curie Memorial Foundation, Research Department, Oxted, Surrey RH8 0TL, The Chart
关键词
D O I
10.1016/0014-2964(79)90028-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Chloroform was administered to mice in their drinking water at a dose level of either 0.15 or 15 mg/kg/day. At the lower dose level chloroform did not significantly alter the rate of multiplication of the Ehrlich ascites cells. Prolonged intake of chloroform at 0.15 mg/kg significantly increased the Lewis lung tumour protein levels although the growth and metastasis in the chloroform-ingesting animals was not significantly different from the controls. The percentage of animals with organs invaded by B 16 melanoma was increased by chloroform ingestion at 0.15 mg/kg. At the higher treatment level the rate of metastasis of the Lewis lung carcinoma and the number of Ehrlich ascites cells were increased. © 1979.
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页码:1485 / 1490
页数:6
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