INHIBITION OF LIPID-PEROXIDATION BY CALCIUM-IONS AND THEIR PROTECTION OF STEROID HYDROXYLASE-ACTIVITY FROM PEROXIDATIVE DAMAGE

被引：8

作者：

IIDA, H ^{[1
]}

KIMURA, T ^{[1
]}

机构：

[1] WAYNE STATE UNIV,DEPT CHEM,DETROIT,MI 48202

来源：

ENDOCRINE RESEARCH COMMUNICATIONS | 1979年 / 6卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.3109/07435807909061795

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lipid peroxidation of adrenocortical mitochondria and microsomes was greatly stimulated by addition of 1.0 mM or less ferric ions. In the presence of NADPH-yielding system, the formation of corticosterone from endogeneous cholesterol and exogeneous deoxycorticosterone was inhibited as the concentrations of iron increased. Of interest is the fact that 0.5 mM ferric ion-mediated lipid peroxidation was completely abrogated upon addition of 2 mM calcium ions. Accordingly, the activity of corticoidogenesis was dramatically protected from the peroxidative damage. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：203 / 212

页数：10

共 9 条

[1]

GORNALL AG, 1949, J BIOL CHEM, V177, P751

[2] EFFECT OF CALCIUM ON PHOSPHOLIPID PEROXIDATION [J].