DO 15-LIPOXYGENASES HAVE A COMMON BIOLOGICAL ROLE

被引：59

作者：

SCHEWE, T

KUHN, H

机构：

[1] Institute of Biochemistry, Medical School (Charité), Humboldt-University, 0-1040 Berlin

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 10期

关键词：

D O I：

10.1016/0968-0004(91)90153-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In contrast to the well-studied role of 5-lipoxygenase in the arachidonic acid cascade that occurs in inflammatory cells, the biological role of the related 15-lipoxygenases in the metabolism of free polyenoic fatty acids is far from clear. However, the activity of 15-lipoxygenases with more complex substrates may play a crucial role in the differentiation and maturation of certain cell types and in the oxidative modification of lipoproteins in the early stages of atherosclerosis.

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页码：369 / 373

页数：5

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