USE OF THE COLOSTRUM-DEPRIVED PIGLET TO EVALUATE PARENTERAL-FEEDING FORMULAS

Several different neonatal and infant piglet models have been invaluable as animal models in nutrition research. A preterm colostrum-deprived piglet model has been developed that is delivered at the desired gestational age, is cared for using the standard of care provided preterm human neonates including procedures for nutritional support and can be studied during pathological conditions induced under controlled conditions. The absolute values for each nutrient requirement would not be expected to be identical for preterm piglets and preterm human neonates. However, the effect of different levels of gestational maturity and superimposed pathophysiologies on nutrient requirements should be similar in the piglet and human neonate.