THYROTROPHIN-RESPONSIVE ADENYLATE-CYCLASE ACTIVITY IN THYROID TOXIC ADENOMA

被引：12

作者：

TOCCAFONDI, RS

ROTELLA, CM

TANINI, A

FANI, P

ARCANGELI, P

机构：

来源：

ACTA ENDOCRINOLOGICA | 1979年 / 92卷 / 04期

关键词：

D O I：

10.1530/acta.0.0920658

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The adenylate cyclase system was studied in hyperfunctioning autonomous nodules in comparison with normal thyroid tissue. The basal, TSH- and NaF-stimulated adenylate cyclase activities were tested in purified plasma membrane preparations. Basal enzyme activity in membranes from hyper-functioning nodules was variable and the response to TSH was either normal, low or absent. The present study demonstrates that an intact adenylate cyclase activity, hyporesponsive to TSH, may exist in the cell membrane of the adenoma.

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页码：658 / 668

页数：11

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