ACUTE MEGAKARYOBLASTIC LEUKEMIA IN CHILDREN AND ADOLESCENTS - A RETROSPECTIVE ANALYSIS OF 24 CASES

被引：47

作者：

RIBEIRO, RC

OLIVEIRA, MSP

FAIRCLOUGH, D

HURWITZ, C

MIRRO, J

BEHM, FG

HEAD, D

SILVA, MLM

RAIMONDI, SC

CRIST, WM

KRANCE, R

机构：

[1] Department of Hematology-Oncology, University of Tennessee, Rio de Janeiro

[2] Department of Pathology and Laboratory Medicine, institutionname, Rio de Janeiro

[3] Departments of Biostatistics, University of Tennessee, Rio de Janeiro

[4] University of Tennessee, Memphis College of Medicine, Memphis, TN

[5] National Institute of Cancer, Rio de Janeiro

[6] Department of St. Jude Children's, Research Hospital, Memphis, TN

来源：

LEUKEMIA & LYMPHOMA | 1993年 / 10卷 / 4-5期

关键词：

ACUTE NONLYMPHOCYTIC LEUKEMIA; MEGAKARYOBLASTIC; FAB; M7; CHILDREN;

D O I：

10.3109/10428199309148552

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In order to characterize the clinical, cytogenetic, and outcome features of childhood acute megakaryoblastic leukemia (AMKL), we reviewed 24 cases; 14 were identified among 150 consecutive newly diagnosed acute myelogenous leukemia (AML) patients at St. Jude Children's Research Hospital, and 10 were cases referred to the National Institute of Cancer in Rio de Janeiro, Brazil. There were 5 Down syndrome patients and one patient with chronic myeloid leukemia (Ph+) in blastic crisis. Twelve patients had significant hepatosplenomegaly. Leukemic cell morphology and cytochemistry were consistent with the M7 classification in 17 cases, and all cases tested expressed megakaryocytic surface antigens. AMKL patients were significantly younger than other AML patients (P = 0.0001) and had poorer responses to therapy (P = 0.03, univariate analysis only). Ten of 24 failed induction, and only 5 are disease-free at 6 months to 4.5+ years. We conclude that AMKL usually affects young children, frequently producing marked organomegaly. It comprises approximately 10% of pediatric AML cases, and responds poorly to intensive AML therapies.

引用

页码：299 / 306

页数：8

共 51 条

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