SHEEP PANCREATIC MICROSOMES AS AN ALTERNATIVE TO THE DOG SOURCE FOR STUDYING PROTEIN TRANSLOCATION

被引:7
作者
KADERBHAI, MA [1 ]
HARDING, VJ [1 ]
KARIM, A [1 ]
AUSTEN, BM [1 ]
KADERBHAI, NN [1 ]
机构
[1] ST GEORGE HOSP,SCH MED,SURG UNIT,LONDON SW17 0RE,ENGLAND
关键词
D O I
10.1042/bj3060057
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A procedure is described for the preparation of rough membrane vesicles of endoplasmic-reticular origin from the pancreas of sheep. These isolated membranes translocate, process and glycosylate in vitro-translated heterologous proteins in a manner comparable with that exhibited by dog pancreatic microsomes.
引用
收藏
页码:57 / 61
页数:5
相关论文
共 25 条
[1]   DESIGN AND SYNTHESIS OF A CONSENSUS SIGNAL SEQUENCE THAT INHIBITS PROTEIN TRANSLOCATION INTO ROUGH MICROSOMAL VESICLES [J].
AUSTEN, BM ;
HERMONTAYLOR, J ;
KADERBHAI, MA ;
RIDD, DH .
BIOCHEMICAL JOURNAL, 1984, 224 (01) :317-325
[2]   PROCESSING INVITRO OF PLACENTAL PEPTIDE-HORMONES BY SMOOTH MICROSOMES [J].
BIELINSKA, M ;
ROGERS, G ;
RUCINSKY, T ;
BOIME, I .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (12) :6152-6156
[3]   TRANSFER OF PROTEINS ACROSS MEMBRANES .2. RECONSTITUTION OF FUNCTIONAL ROUGH MICROSOMES FROM HETEROLOGOUS COMPONENTS [J].
BLOBEL, G ;
DOBBERSTEIN, B .
JOURNAL OF CELL BIOLOGY, 1975, 67 (03) :852-862
[4]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[5]   ROLE OF ORGANELLES IN CHEMICAL MODIFICATION OF PRIMARY TRANSLATION PRODUCTS OF SECRETORY PROTEINS [J].
CAMPBELL, PN ;
BLOBEL, G .
FEBS LETTERS, 1976, 72 (02) :215-226
[6]   YEAST PHEROMONE ALPHA-FACTOR IS SYNTHESIZED AS A HIGH MOLECULAR-WEIGHT PRECURSOR [J].
EMTER, O ;
MECHLER, B ;
ACHSTETTER, T ;
MULLER, H ;
WOLF, DH .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 116 (03) :822-829
[7]   INVITRO PROTEIN TRANSLOCATION ACROSS THE YEAST ENDOPLASMIC-RETICULUM - ATP-DEPENDENT POSTTRANSLATIONAL TRANSLOCATION OF THE PREPRO-ALPHA-FACTOR [J].
HANSEN, W ;
GARCIA, PD ;
WALTER, P .
CELL, 1986, 45 (03) :397-406
[8]   PROCESSING OF CHIMERIC MAMMALIAN CYTOCHROME B(5) PRECURSORS IN ESCHERICHIA-COLI - REACTION SPECIFICITY OF SIGNAL PEPTIDASE AND IDENTIFICATION OF AN AMINOPEPTIDASE IN POST-TRANSLOCATIONAL PROCESSING [J].
HARDING, V ;
KARIM, A ;
KADERBHAI, N ;
JONES, A ;
EVANS, A ;
KADERBHAI, MA .
BIOCHEMICAL JOURNAL, 1993, 293 :751-756
[9]   GLYCOSYLATION AND PROCESSING OF PREPRO-ALPHA-FACTOR THROUGH THE YEAST SECRETORY PATHWAY [J].
JULIUS, D ;
SCHEKMAN, R ;
THORNER, J .
CELL, 1984, 36 (02) :309-318
[10]   DOG PANCREATIC MICROSOMAL-MEMBRANE POLYPEPTIDES ANALYZED BY TWO-DIMENSIONAL GEL-ELECTROPHORESIS [J].
KADERBHAI, MA ;
AUSTEN, BM .
BIOCHEMICAL JOURNAL, 1984, 217 (01) :145-157