2 NEW BIOACTIVE TRITERPENOIDS FROM MELIA-VOLKENSII (MELIACEAE)

被引：21

作者：

ZENG, L

GU, ZM

FANG, XP

FANWICK, PE

CHANG, CJ

SMITH, DL

MCLAUGHLIN, JL

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

[2] PURDUE UNIV,SCH SCI,DEPT CHEM,W LAFAYETTE,IN 47907

来源：

TETRAHEDRON | 1995年 / 51卷 / 09期

基金：

美国国家卫生研究院;

关键词：

MELIA VOLKENSII; MELIAVOLIN; MELIAVOLKIN; BRINE SHRIMP LETHALITY; HUMAN SOLID TUMOR CYTOTOXICITIES;

D O I：

10.1016/0040-4020(95)00018-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Meliavolin (1), a new triterpene with an apotirucallane skeleton, and meliavolkin (2), a new tetranortriterpene, together with melianin A, a known compound, have been isolated from the root bark of Melia volkensii (Meliaceae) by using activity-directed fractionation with brine shrimp. The structures have been elucidated by spectral data. The relative and absolute stereochemistry of meliavolin (1) was determined by analysis of Mosher ester derivatives, 1e and 1f, and by X-ray crystallographic analysis of meliavolin diacetate, 1c. 1 and melianin A showed marginal cytotoxicities to certain human tumor cell lines, but 2 was significantly more cytotoxic, showing equivalent potency to adriamycin against the human breast tumor cell line (MCF-7).

引用

页码：2477 / 2488

页数：12

共 19 条

[1] CONVERSION OF TURRAEANTHIN AND TURRAEANTHIN-A INTO SIMPLE MELIACINS BY A ROUTE INVOLVING AN OXIDATIVE REARRANGEMENT OF PROBABLE BIOGENETIC IMPORTANCE [J].