S-(2-OXOPENTADECYL)-COA, A NONHYDROLYZABLE ANALOG OF MYRISTOYL-COA, IS A POTENT INHIBITOR OF MYRISTOYL-COA-PROTEIN N-MYRISTOYLTRANSFERASE

被引：45

作者：

PAIGE, LA

ZHENG, GQ

DEFREES, SA

CASSADY, JM

GEAHLEN, RL

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACEUT SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

[2] OHIO STATE UNIV,COLL PHARM,COLUMBUS,OH 43210

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1989年 / 32卷 / 08期

关键词：

D O I：

10.1021/jm00128a001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1665 / 1667

页数：3

共 17 条

[1] Bloxham D P, 1981, Methods Enzymol, V72, P592
[2] MYRISTIC ACID, A RARE FATTY-ACID, IS THE LIPID ATTACHED TO THE TRANSFORMING PROTEIN OF ROUS-SARCOMA VIRUS AND ITS CELLULAR HOMOLOG
BUSS, JE
SEFTON, BM
[J]. JOURNAL OF VIROLOGY, 1985, 53 (01) : 7 - 12
[3] MYRISTYLATION OF PICORNAVIRUS CAPSID PROTEIN VP4 AND ITS STRUCTURAL SIGNIFICANCE
CHOW, M
NEWMAN, JFE
FILMAN, D
HOGLE, JM
ROWLANDS, DJ
BROWN, F
[J]. NATURE, 1987, 327 (6122) : 482 - 486
[4] CIARDELLI T, 1981, LIEBIGS ANN CHEM, P828
[5] A SHORT SEQUENCE IN THE P60SRC N-TERMINUS IS REQUIRED FOR P60SRC MYRISTYLATION AND MEMBRANE ASSOCIATION AND FOR CELL-TRANSFORMATION
CROSS, FR
GARBER, EA
PELLMAN, D
HANAFUSA, H
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1984, 4 (09) : 1834 - 1842
[6] HEUCKEROTH RO, 1988, J BIOL CHEM, V263, P2127
[7] HETEROATOM-SUBSTITUTED FATTY-ACID ANALOGS AS SUBSTRATES FOR N-MYRISTOYLTRANSFERASE - AN APPROACH FOR STUDYING BOTH THE ENZYMOLOGY AND FUNCTION OF PROTEIN ACYLATION
HEUCKEROTH, RO
GLASER, L
GORDON, JI
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) : 8795 - 8799
[8] MUTATION OF NH-2-TERMINAL GLYCINE OF P60SRC PREVENTS BOTH MYRISTOYLATION AND MORPHOLOGICAL TRANSFORMATION
KAMPS, MP
BUSS, JE
SEFTON, BM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (14) : 4625 - 4628
[9] CAPSID PROTEIN VP4 OF POLIOVIRUS IS N-MYRISTOYLATED
PAUL, AV
SCHULTZ, A
PINCUS, SE
OROSZLAN, S
WIMMER, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (22) : 7827 - 7831
[10] THE PRES1 PROTEIN OF HEPATITIS-B VIRUS IS ACYLATED AT ITS AMINO TERMINUS WITH MYRISTIC ACID
PERSING, DH
VARMUS, HE
GANEM, D
[J]. JOURNAL OF VIROLOGY, 1987, 61 (05) : 1672 - 1677

← 1 2 →