Structural studies of the O-antigen from Vibrio cholerae O : 2

被引：38

作者：

Kenne, Lennart

Lindberg, Bengt

Schweda, Elke

Gustafsson, Bjoern ^{[1
]}

Holme, Tord

机构：

[1] Karolinska Inst, Dept Bacteriol, S-10401 Stockholm, Sweden

[2] Univ Stockholm, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

[3] Natl Bacteriol Lab, Dept Vaccine Prod, S-10521 Stockholm, Sweden

来源：

CARBOHYDRATE RESEARCH | 1988年 / 180卷 / 02期

关键词：

D O I：

10.1016/0008-6215(88)80085-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of the O-antigen from Vibrio cholerae O:2 has been investigated, mainly by methylation analysis, specific degradations, and n.m.r. spectroscopy, and concluded to involve the trisaccharide repeating-unit -> 4)-beta-D-QuipNAc-(1 -> 4)-Sugp-(2 -> 4)-beta-D-Galp-(1 ->, in which QuiNAc is 2-acetamido-2,6-dideoxyglucose and Sug is tentatively assigned as 5-acetamidino-7-acetamido-3,5,7,9-tetradeoxy-L-glycero-beta-L-manno-nonulosonit acid.The acetamidino group is basic and, consequently, the polysaccharide is neutral.When this group is transformed into an N-acetyl group, by treatment with aqueous triethylamine, the polysaccharide becomes acidic.

引用

页码：285 / 294

页数：10

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