IMPROVED SYNTHESIS OF FLUOROALKYL AND FLUOROARYL SUBSTITUTED 2-AMINOPYRIMIDINES

被引：6

作者：

KUCEROVY, A

MATTNER, PG

HATHAWAY, JS

REPIC, O

机构：

[1] Chemical Research and Development, Sandoz Pharmaceuticals Corporation

来源：

SYNTHETIC COMMUNICATIONS | 1990年 / 20卷 / 06期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1080/00397919008052340

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fluoroalkyl and fluoroaryl substituted 2-aminopyrimidines have been prepared in good yields by the cyclization of guanidine salts with fluorine substituted β-diketones in sodium isopropoxide/isopropanol at reflux. Copyright © 1990 by Taylor & Francis Group. All rights reserved.

引用

页码：913 / 917

页数：5

共 10 条

[1] BIRESSI MG, 1965, GAZZ CHIM ITAL, V96, P1293
[2] BROWN DJ, 1985, PYRIMIDINES S2, V16, P28
[3] ELDERFIELD RC, 1957, HETEROCYCL COMPOUNDS, V6, P232
[4] POTENTIAL ANTINEOPLASTICS .I. 2-AMINO-4,6-DIMETHYL-5-ARYLAZOPYRIMIDINES AND 1-THIOCARBAMOYL-3,5-DIPHENYL-4-ARYLAZOPYRAZOLES
GARG, HG
SHARMA, RA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (06) : 1122 - &
[5] NITRILE OXIDES .9. BASIC SUBSTITUTED STABLE NITRILE OXIDES
GRUNDMANN, C
RICHTER, R
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1967, 32 (07) : 2308 - +
[6] ANALGESICS .8. FLUOROALKYLSUBSTITUTED 2-(ETHYLAMINO)PYRIMIDINE
KREUTZBERGER, A
LEYKEROHLING, S
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1978, 15 (07) : 1097 - 1099
[7] A NOVEL REACTION OF CYANAMIDE WITH 1,3-DIKETONES
MILLER, A
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (21) : 4072 - 4074
[8] STUDIES ON HETEROCYCLIC CHEMISTRY .4. PREPARATION OF SEVERAL TRIFLUOROMETHYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS AND OBSERVATION OF METASTABLE ION IN MASS SPECTRA OF TRIFLUOROMETHYL-PYRAZOLES
NISHIWAKI, T
[J]. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1969, 42 (10) : 3024 - +
[9] RORIG KJ, 1956, Patent No. 2748119
[10] 4 ROUTES FOR SYNTHESIS OF (2-PYRIMIDINYLAMINO)-N-ALKANOIC ACIDS
TJOENG, FS
KRAAS, E
STARK, E
BREITMAIER, E
JUNG, G
[J]. CHEMISCHE BERICHTE-RECUEIL, 1975, 108 (03): : 862 - 874

← 1 →