LETHAL MYOTOXIN ISOLATED FROM THE VENOM OF THE AUSTRALIAN KING BROWN SNAKE (PSEUDECHIS-AUSTRALIS)

被引：28

作者：

LEONARDI, TM ^{[1
]}

HOWDEN, MEH ^{[1
]}

SPENCE, I ^{[1
]}

机构：

[1] ROCHE RES INST MARINE PHARMACOL,DEPT PHARMACOL,DEE WHY 2099,NEW S WALES,AUSTRALIA

来源：

TOXICON | 1979年 / 17卷 / 06期

关键词：

D O I：

10.1016/0041-0101(79)90229-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A lethal myotoxin, named mulgotoxin a, was isolated from the venom of the Australian king brown snake (Pseudechis australis) by chromatography on Biorex 70 and SP-Sephadex ion exchange resins. Mulgotoxin a was obtained from one of four lethal fractions which were present in the venom. Mulgotoxin a is a basic toxin consisting of a single polypeptide chain of 122 amino acid residues cross-linked by seven disulphide bridges. Its N-and C-terminal residues are aspartic acid and leucine respectively. Mulgotoxin a causes myoglobinuria in mice and has an approximate ld50 of 200 μg/kg body weight (mice). Its activity appears to be specific for skeletal muscle, causing massive cell damage both in vivo and in vitro. © 1979.

引用

页码：549 / 555

页数：7

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