PROTEIN-KINASE-C IN TRANSMEMBRANE SIGNALING

被引：201

作者：

FARAGO, A ^{[1
]}

NISHIZUKA, Y ^{[1
]}

机构：

[1] KOBE UNIV,SCH MED,DEPT BIOCHEM,KOBE 650,JAPAN

来源：

FEBS LETTERS | 1990年 / 268卷 / 02期

关键词：

Protein kinase C; molecular heterogeneity; signal routes for activation: Protein kinase C down regulation: Protein kinase C. physiological roles; Signal transduction;

D O I：

10.1016/0014-5793(90)81284-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein kinase C functions as the transducer of a second messenger, diacylglycerol, and is the major receptor for tumour-promoting phorbol esters. The enzyme is a family of proteins with closely but distinct structures and individual enzymological properties. Members of the family are differently distributed in particular cell types and limited intracellular locations from lower organisms to mammalian tissues. The enzyme appears to interact with many signalling pathways, and display functions in the processing and modulation of cellular responses to external stimuli. Presumably, each member of the family plays discrete roles in the control of a variety of membrane functions and activation of gene transcription. © 1990.

引用

页码：350 / 354

页数：5

共 75 条

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