PRELIMINARY EVIDENCE FOR HOMEOSTATIC MECHANISM REGULATING ENDOTHELIN PRODUCTION IN PREECLAMPSIA

被引：38

作者：

BRANCH, DW

DUDLEY, DJ

MITCHELL, MD

机构：

[1] Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT

来源：

LANCET | 1991年 / 337卷 / 8747期

基金：

新加坡国家研究基金会;

关键词：

D O I：

10.1016/0140-6736(91)91572-C

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To find out whether a serum factor in pre-eclamptic women is the cause of the raised serum endothelin concentrations associated with the disorder, the effect of serum from pre-eclamptic women on endothelin production by endothelial cells was compared with that of serum from pregnant and non-pregnant controls. The finding that pre-eclamptic serum suppresses endothelin production suggests that it contains a factor that might be part of a homoeostatic response to raised serum endothelin concentrations in pre-eclampsia.

引用

页码：943 / 945

页数：3

共 11 条

[1]

CUNNINGHAM FG, 1989, HYPERTENSIVE DISORDE

[2] PATHOPHYSIOLOGY OF ANTIPHOSPHOLIPID ANTIBODIES - ABSENCE OF PROSTAGLANDIN-MEDIATED EFFECTS ON CULTURED ENDOTHELIUM [J].