DETERMINATION OF ANTIMONY IN BIOLOGICAL-MATERIALS BY ELECTRO-THERMAL ATOMIC-ABSORPTION SPECTROSCOPY

被引：15

作者：

WARD, RJ ^{[1
]}

BLACK, CDV ^{[1
]}

WATSON, GJ ^{[1
]}

机构：

[1] ZOOL SOC LONDON,INST ZOOL,NUFFIELD COMPARAT MED LAB,LONDON NW1 4RY,ENGLAND

来源：

CLINICA CHIMICA ACTA | 1979年 / 99卷 / 02期

关键词：

D O I：

10.1016/0009-8981(79)90037-8

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

An electrothermal atomic absorption method for the determination of antimony in biological fluids, derived from Triostam or Pentostam, is described. Comparison of the results obtained by this method has been made with hydride generation atomic absorption and by measuring the 7 emission of 125Sb-Pentostam. Using electrothermal atomic absorption, the concentrations and distributions of the pentavalent and trivalent antimony drugs, either in free or liposome-entrapped forms, have been determined in vitro after incubation with human blood. The effect of entrapping Pentostam within liposomes has also been studied in vivo in mice, and its concentration and distribution compared with results obtained using the free drug. © 1979.

引用

页码：143 / 152

页数：10

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