TGF-BETA - UPREGULATOR OF HIV REPLICATION IN MACROPHAGES

被引：21

作者：

LAZDINS, JK

KLIMKAIT, T

ALTERI, E

WALKER, M

WOODSCOOK, K

COX, D

BILBE, G

SHIPMAN, R

CERLETTI, N

MCMASTER, G

机构：

[1] Ciba-Geigy, Ltd., Pharma Research, Basel

来源：

RESEARCH IN VIROLOGY | 1991年 / 142卷 / 2-3期

关键词：

TRANSFORMING GROWTH FACTOR; HIV; MACROPHAGE; TGF-BETA; UP-REGULATION;

D O I：

10.1016/0923-2516(91)90063-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

TGF-beta at physiological concentrations, when added to monocyte-derived macrophages following HIV 1 infection, has an enhancing effect upon the rate of virus production. This effects is observed with the monocytotropic isolate ADA, as well as with HIV 1 IIIB, which poorly replicates in macrophages.

引用

页码：239 / 242

页数：4

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