ADDITIONAL BIOACTIVE COMPOUNDS AND TRILOBACIN, A NOVEL HIGHLY CYTOTOXIC ACETOGENIN, FROM THE BARK OF ASIMINA-TRILOBA

被引:117
作者
ZHAO, GX
HUI, YH
RUPPRECHT, JK
MCLAUGHLIN, JL
WOOD, KV
机构
[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907
[2] PURDUE UNIV,SCH SCI,DEPT CHEM,W LAFAYETTE,IN 47907
来源
JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 03期
关键词
D O I
10.1021/np50081a011
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Fractionation of the EtOH extract of the bark of Asimina triloba, monitoring by brine shrimp lethality, has led to the isolation and structural elucidation of a novel highly cytotoxic Annonaceous acetogenin, trilobacin [1], in addition to six known compounds: asimicin [2], bullatacin [3], bullatacinone [4], N-p-coumaroyltyramine [5], N-trans-feruloyl-tyramine [6], and (+)-syringaresinol [7]. Acetogenin 1 was identified as a diastereomer of asimicin [2] by spectral and chemical methods, and both 1 and 2 showed potent and selective cytotoxicities in the NCI human tumor cell line screen.
引用
收藏
页码:347 / 356
页数:10
相关论文
共 24 条
  • [1] BEVALOT F, 1977, ANN PHARM FR, V35, P65
  • [2] BLAGOVESHCHENSK.AV, 1965, T MOSK OVA ISPYT PRI, V13, P7
  • [3] CALLAWAY MB, 1990, PAWPAW ASIMINA TRILO, P1
  • [4] DEYAMA T, 1983, CHEM PHARM BULL, V31, P2993
  • [5] FARNSWORTH NR, 1974, LYNN INDEX MONOGRAPH, V8, P60
  • [6] MODIFICATION AND EVALUATION OF THE POTATO DISK ASSAY AND ANTI-TUMOR SCREENING OF EUPHORBIACEAE SEEDS
    FERRIGNI, NR
    PUTNAM, JE
    ANDERSON, B
    JACOBSEN, LB
    NICHOLS, DE
    MOORE, DS
    MCLAUGHLIN, JL
    POWELL, RG
    SMITH, CR
    [J]. JOURNAL OF NATURAL PRODUCTS, 1982, 45 (06): : 679 - 686
  • [7] Fogh J., 1975, HUMAN TUMOR CELLS IN, P115
  • [8] IN-VITRO CULTIVATION OF HUMAN TUMORS - ESTABLISHMENT OF CELL LINES DERIVED FROM A SERIES OF SOLID TUMORS
    GIARD, DJ
    AARONSON, SA
    TODARO, GJ
    ARNSTEIN, P
    KERSEY, JH
    DOSIK, H
    PARKS, WP
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1973, 51 (05) : 1417 - 1423
  • [9] GIBBS RD, 1974, CHEMOTAXONOMY FLOWER, P289
  • [10] HEGNAUER R, 1964, CHEMOTAXONOMIE PFLAN, V3, P116