OCULAR EFFECTS OF ENDOTHELIN-1 IN THE CAT

被引：70

作者：

GRANSTAM, E ^{[1
]}

WANG, L ^{[1
]}

BILL, A ^{[1
]}

机构：

[1] UNIV UPPSALA,DEPT MED BIOPHYS,S-75123 UPPSALA,SWEDEN

来源：

CURRENT EYE RESEARCH | 1992年 / 11卷 / 04期

关键词：

D O I：

10.3109/02713689209001786

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The effects of intravitreal and intracameral administration of endothelin- 1 were studied in the anaesthetized cat. Intravitreal injection of 0.4 nmol endothelin-1 induced a 34 +/- 10% (n = 5; P < 0.05) reduction in retinal blood flow in the experimental eye compared to the control eye 80 minutes after the injection. Blood flow in the ciliary body, iris and choroid remained unaffected by the injection of endothelin-1. Intracameral administration of endothelin- 1 at pmol doses caused a reduction in pupil size, an increase in the aqueous humor protein concentration (indicating a break-down of the blood-aqueous barrier) and an increase in the concentration of prostaglandin E2 in the aqueous humor. The effect of endothelin-1 on pupil size was abolished by indomethacin pretreatment, indicating that this effect was mediated by arachidonic acid metabolites.

引用

页码：325 / 332

页数：8

共 31 条

[1] ENDOTHELIN-1 STIMULATES THE RELEASE OF ARACHIDONIC-ACID AND PROSTAGLANDINS IN RABBIT IRIS SPHINCTER SMOOTH-MUSCLE - ACTIVATION OF PHOSPHOLIPASE-A2 [J].