EVIDENCE THAT GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR REGULATES THE DISTRIBUTION AND DIFFERENTIATED STATE OF DENDRITIC CELLS LANGERHANS CELLS IN HUMAN LUNG AND LUNG CANCERS

被引:187
作者
TAZI, A
BOUCHONNET, F
GRANDSAIGNE, M
BOUMSELL, L
HANCE, AJ
SOLER, P
机构
[1] UNIV PARIS 07, INSERM, U82, 16 RUE HENRI HUCHARD, F-75018 PARIS, FRANCE
[2] HOP AVICENNE, SERV PNEUMOL, F-93009 BOBIGNY, FRANCE
[3] HOP ST LOUIS, INSERM, U93, F-75010 PARIS, FRANCE
关键词
GRANULOCYTE MACROPHAGE; COLONY-STIMULATING FACTOR; LANGERHANS CELLS; DENDRITIC CELLS; HUMAN LUNG; LUNG CANCERS;
D O I
10.1172/JCI116236
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
GM-CSF has been shown to be important for the survival and function of cells of dendritic cell/Langerhans cell (LC) lineage in vitro. Since these cells have been demonstrated to infiltrate human lung and some lung carcinomas, we hypothesized that the production of GM-CSF in the lung could be important in their recruitment and differentiation. Using both immunohistochemistry and in situ hybridization, we have shown that: (a) GM-CSF was produced by normal bronchiolar epithelium, the only site were CD1a+ LC are observed in the normal lung, whereas neither GM-CSF production nor LC were identified in normal alveolar epithelium. (b) In inflamed pulmonary tissue, hyperplastic alveolar cells produced GM-CSF, and CD1a+ LC accumulated adjacent to these cells. (c) Some, but not all, lung carcinomas produced this cytokine, and a close correlation was found between the production of GM-CSF and the number of CD1a+ LC infiltrating these tumors. Since GM-CSF was produced at all sites where CD1a+ LC are known to accumulate, but not at other locations within the lung, these data suggest that the local production of GM-CSF by certain lung cells may play an important role in determining the distribution and differentiated state of dendritic cell/LC in the human lung.
引用
收藏
页码:566 / 576
页数:11
相关论文
共 42 条
  • [1] AMIOT M, 1986, J IMMUNOL, V136, P1752
  • [2] BASSET F, 1986, ANN NY ACAD SCI, V465, P325
  • [3] BERNAUDIN JF, 1988, J IMMUNOL, V140, P3822
  • [4] BROUDY VC, 1987, J IMMUNOL, V139, P464
  • [5] BURGESS AW, 1987, BLOOD, V69, P43
  • [6] LANGERHANS CELLS IN HUMAN-LUNG TUMORS - AN IMMUNOHISTOLOGICAL STUDY
    FOX, SB
    JONES, M
    DUNNILL, MS
    GATTER, KC
    MASON, DY
    [J]. HISTOPATHOLOGY, 1989, 14 (03) : 269 - 275
  • [7] THE IMMUNOBIOLOGY OF LANGERHANS CELLS
    FRIEDMANN, PS
    [J]. IMMUNOLOGY TODAY, 1981, 2 (07): : 124 - 128
  • [8] FURUKAWA T, 1985, CANCER, V56, P2651, DOI 10.1002/1097-0142(19851201)56:11<2651::AID-CNCR2820561120>3.0.CO
  • [9] 2-E
  • [10] INTRAEPITHELIAL AIRWAY DENDRITIC CELLS - A DISTINCT SUBSET OF PULMONARY DENDRITIC CELLS OBTAINED BY MICRODISSECTION
    GONG, JL
    MCCARTHY, KM
    TELFORD, J
    TAMATANI, T
    MIYASAKA, M
    SCHNEEBERGER, EE
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (03) : 797 - 807