PHOSPHOLIPASE-LIKE MYOTOXINS INDUCE RAPID MEMBRANE LEAKAGE OF NONHYDROLYZABLE ETHER-LIPID LIPOSOMES

被引：39

作者：

PEDERSEN, JZ

DEARCURI, BF

MORERO, RD

RUFINI, S

机构：

[1] UNIV ROMA TOR VERGATA,DEPT BIOL,I-00133 ROME,ITALY

[2] UNIV NACL TUCUMAN,INST QUIM BIOL QUIM & FARM,TUCUMAN,TUCUMAN,ARGENTINA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1994年 / 1190卷 / 01期

关键词：

PHOSPHOLIPASE A(2); MYOTOXIN; LIPOSOME; MEMBRANE LEAKAGE; SNAKE VENOM;

D O I：

10.1016/0005-2736(94)90049-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two phospholipase-like myotoxins - ammodytin L from Vipera ammodytes and myotoxin II from Bothrops asper - are shown to be able to induce leakage of liposomes made from non-hydrolyzable ether-linked phospholipids. This demonstrates that the cytolytic activity of these toxins is completely independent of any remaining enzyme activity or contamination with active phospholipases.

引用

页码：177 / 180

页数：4

共 29 条

[1] EFFECTS OF CHEMICAL MODIFICATION ON ENZYMATIC AND TOXICOLOGICAL PROPERTIES OF PHOSPHOLIPASES A2 FROM NAJA-NAJA-NAJA AND VIPERA-RUSSELLI SNAKE-VENOMS [J].