SPONTANEOUS CYCLIZATION OF THE ASPARTIC-ACID SIDE-CHAIN TO THE SUCCINIMIDE DERIVATIVE

被引：26

作者：

CAPASSO, S ^{[1
]}

MAZZARELLA, L ^{[1
]}

SICA, F ^{[1
]}

ZAGARI, A ^{[1
]}

SALVADORI, S ^{[1
]}

机构：

[1] UNIV FERRARA,DEPT PHARMACEUT SCI,I-44100 FERRARA,ITALY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 12期

关键词：

D O I：

10.1039/c39920000919

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

At equilibrium in acidic solution the succinimide derivative, formed by cyclization reaction of the Asp side chain, predominates; at a pH close to the apparent pK(a) of the Asp residue this reaction is relatively fast with a t1/2 of a few days.

引用

页码：919 / 921

页数：3

共 11 条

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ROBSON, VMJ
RAE, ID
NG, F
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[J]. PROTEIN ENGINEERING, 1991, 4 (03): : 283 - 294

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