NEUROPROTECTIVE EFFECT OF PHENYLSUCCINATE, AN INHIBITOR OF CYTOSOLIC GLUTAMATE FORMATION FROM GLUTAMINE, UNDER ANOXIC CONDITIONS BUT NOT DURING EXPOSURE TO EXOGENOUS GLUTAMATE

被引：11

作者：

HUANG, R

HERTZ, L

机构：

[1] UNIV SASKATCHEWAN, DEPT PHARMACOL, SASKATOON, SK S7N 0W0, CANADA

[2] UNIV SASKATCHEWAN, SASKATCHEWAN STROKE RES CTR, SASKATOON, SK S7N 0W0, CANADA

来源：

NEUROSCIENCE LETTERS | 1995年 / 183卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

ANOXIA; CEREBELLAR GRANULE CELLS; EXCITOTOXICITY; GLUTAMATE; GLUTAMINE; LACTATE DEHYDROGENASE; NEURONAL CELL DEATH; PHENYLSUCCINATE;

D O I：

10.1016/0304-3940(94)11106-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Phenylsuccinate is an inhibitor of cytosolic glutamate formation from extracellular glutamine in cultured cerebellar granule cell neurons, a glutamatergic preparation. It prevents anoxic cell death in these cells as indicated by decreased lactate dehydrogenase (LDH) release and by the morphological appearance of the cells after the insult. In contrast, it does not prevent neurotoxicity by added glutamate because it is not an antagonist of the glutamate receptor.

引用

页码：22 / 26

页数：5

共 17 条

[1] EFFECT OF PHENYLSUCCINATE ON POTASSIUM-INDUCED AND ISCHEMIA-INDUCED RELEASE OF GLUTAMATE IN RAT HIPPOCAMPUS MONITORED BY MICRODIALYSIS [J].