REACTIVITY TOWARD SINGLET OXYGEN OF A 7,8-DIHYDRO-8-OXOGUANOSINE (8-HYDROXYGUANOSINE) FORMED BY PHOTOOXIDATION OF A GUANOSINE DERIVATIVE

被引：126

作者：

SHEU, C ^{[1
]}

FOOTE, CS ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,DEPT CHEM & BIOCHEM,LOS ANGELES,CA 90024

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1995年 / 117卷 / 24期

关键词：

D O I：

10.1021/ja00129a004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Total quenching (k(r) + k(q)) and chemical reaction rates (k(r)) for the removal of singlet oxygen by 2,3',5'-tris((tert-butyldimethylsilyl)oxy)guanos (1) and its oxidation product, 2',3',5'-tris((tert-butyldimethylsilyl)oxy)-7,8-dihydro-8-oxoguanosine (2), were determined by the time-resolved infrared luminescence technique and competition experiments, respectively. Compound 2 is two orders of magnitude more reactive with singlet oxygen than 1. A mechanism for the formation of 2 from 1 with singlet oxygen is proposed.

引用

页码：6439 / 6442

页数：4

共 32 条

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