ANTIBODIES TO FIBRONECTIN BIND TO PLAQUES AND OTHER STRUCTURES IN ALZHEIMERS-DISEASE AND CONTROL BRAIN

被引：30

作者：

HOWARD, J

PILKINGTON, GJ

机构：

[1] Department of Neuropathology, Institute of Psychiatry, London

来源：

NEUROSCIENCE LETTERS | 1990年 / 118卷 / 01期

关键词：

Alzheimer's disease; Fibronectin; Immunohistochemistry; Senile plaque;

D O I：

10.1016/0304-3940(90)90251-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Antibodies to fibronectin (Fn) bind not only the basal lamina in Alzheimer's disease brain, but also crystal-like formations in the grey matter, senile plaques, a subset of neuronal perikarya, and large highly processed stellate formations which were both neurofilament and glial fibrillary acidic protein (GFAP) negative and which were identified at a lower frequency in non-demented control brains. © 1990.

引用

收藏

页码：71 / 76

页数：6

相关论文

共 15 条

[1] IMMUNOCHEMICAL IDENTIFICATION OF THE SERINE PROTEASE INHIBITOR ALPHA-1-ANTICHYMOTRYPSIN IN THE BRAIN AMYLOID DEPOSITS OF ALZHEIMERS-DISEASE [J].

ABRAHAM, CR ;

SELKOE, DJ ;

POTTER, H .

CELL, 1988, 52 (04) :487-501

[2] IMMUNOREACTIVE EPIDERMAL GROWTH-FACTOR RECEPTORS IN NEURITIC PLAQUES FROM PATIENTS WITH ALZHEIMERS-DISEASE [J].

BIRECREE, E ;

WHETSELL, WO ;

STOSCHECK, C ;

KING, LE ;

NANNEY, LB .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1988, 47 (05) :549-560

[3]

CORIA F, 1988, LAB INVEST, V58, P454

[4] FIBRONECTIN AND C4-BINDING PROTEIN ARE SELECTIVELY BOUND BY AGGREGATED AMYLOID-P COMPONENT [J].

DEBEER, FC ;

BALTZ, ML ;

HOLFORD, S ;

FEINSTEIN, A ;

PEPYS, MB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1981, 154 (04) :1134-1149

[5] ANTIVASCULAR ANTIBODIES IN THE SERA OF PATIENTS WITH SENILE DEMENTIA OF THE ALZHEIMERS TYPE [J].

FILLIT, HM ;

KEMENY, E ;

LUINE, V ;

WEKSLER, ME ;

ZABRISKIE, JB .

JOURNALS OF GERONTOLOGY, 1987, 42 (02) :180-184

[6]

IKEDA S, 1989, LAB INVEST, V60, P113

[7]

KAWAHARA E, 1989, AM J PATHOL, V134, P1305

[8]

KITAMOTO T, 1987, LAB INVEST, V57, P230

[9] IMMUNOHISTOCHEMICAL STUDY OF ALZHEIMERS-DISEASE USING ANTIBODIES TO SYNTHETIC AMYLOID AND FIBRONECTIN [J].

KOIKE, F ;

KUNISHITA, T ;

NAKAYAMA, H ;

TABIRA, T .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1988, 85 (01) :9-15

[10] MONOCLONAL-ANTIBODY TO EMBRYONIC CNS ANTIGEN A2B5 PROVIDES EVIDENCE FOR THE INVOLVEMENT OF MEMBRANE-COMPONENTS AT SITES OF ALZHEIMER DEGENERATION AND DETECTS SULFATIDES AS WELL AS GANGLIOSIDES [J].

MAJOCHA, RE ;

JUNGALWALA, FB ;

RODENRYS, A ;

MAROTTA, CA .

JOURNAL OF NEUROCHEMISTRY, 1989, 53 (03) :953-961