KAPPA-OPIOID AGONIST INHIBITS PHOSPHOLIPASE-C, POSSIBLY VIA AN INHIBITION OF G-PROTEIN ACTIVITY

被引：29

作者：

MISAWA, H ^{[1
]}

UEDA, H ^{[1
]}

SATOH, M ^{[1
]}

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,SAKYO KU,KYOTO 606,JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 112卷 / 2-3期

关键词：

GTP-binding protein; Phospholipase C; κ-Opioid receptor;

D O I：

10.1016/0304-3940(90)90224-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In synaptic membranes of guinea pig cerebellum, in which preparations U-50, 488H, a κ-opioid agonist inhibits G-protein activity, the same κ-agonist at 100 nM inhibited the phospholipase C (PLC) activity stimulated by 100 μM GTP in the presence of 10 μM Ca2+. The present study provides a unique hypothetical mechanism that the receptor-mediated inhibition of PLC is mediated by inhibition of G-protein activity. © 1990.

引用

页码：324 / 327

页数：4

共 16 条

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