PREDICTING PHENYTOIN DOSE - REVISED NOMOGRAM

被引：62

作者：

RAMBECK, B ^{[1
]}

BOENIGK, HE ^{[1
]}

DUNLOP, A ^{[1
]}

MULLEN, PW ^{[1
]}

WADSWORTH, J ^{[1
]}

RICHENS, A ^{[1
]}

机构：

[1] NATL HOSP,INST NEUROL,CLIN PHARMACOL UNIT,LONDON WC1N 3BG,ENGLAND

来源：

THERAPEUTIC DRUG MONITORING | 1979年 / 1卷 / 03期

关键词：

Epilepsy; Nomogram; Phenytoin;

D O I：

10.1097/00007691-197901030-00007

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The nomogram devised by Richens and Dunlop for predicting Phenytoin dose has been tested in 127 residential epileptic patients, and the data obtained were used to prepare a revised version of the nomogram. In a further 78 patients, this new version was found to be superior to the original. The mean Km value was found to be 23.8 µmoles/liter. Km was independent of age and body surface area, but Dmax correlated positively with the latter two variables. © 1979 Raven Press, New York.

引用

页码：325 / 333

页数：9

共 11 条

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