EFFECT OF 6-ETHYL-3-(1H-TETRAZOL-5-YL)CHROMONE (AA-344) ON THE IMMEDIATE AND DELAYED-HYPERSENSITIVITY REACTIONS

被引：11

作者：

KURIKI, H

SAIJO, T

ASHIDA, Y

MAKI, Y

机构：

[1] Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd., Yodogawa-ku

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1979年 / 29卷 / 05期

关键词：

D O I：

10.1254/jjp.29.733

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Effects of 6-ethyl-3-(1 H-tetrazol-5-yl)chromone (AA-344) on the experimental models of the type I-I V allergic reactions were studied in comparison with those of disodium cromoglycate (DSCG), dexamethasone and other agents. AA-344 showed inhibitory effects on the homologous passive cutaneous anaphylaxis and the passive systemic anaphylaxis in guinea pigs. However, it had only a slight or little effect on the Forssman shock in guinea pigs, the complement-dependent cytolysis of mast cells in rats, the Arthus reaction in guinea pigs and the tuberculin reaction and the contact sensitivity in mice. DSCG was less effective, using these experimental models. Dexamethasone showed a suppressive effect on the type III and IV allergic reactions. The results indicate that AA-344 selectively suppresses the type I allergic reaction. © 1979, The Japanese Pharmacological Society. All rights reserved.

引用

页码：733 / 744

页数：12

共 37 条

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