PLASMIN INHIBITORY EFFECT OF RAT-TISSUES - COMPARISON WITH ANTIPLASMIN ACTIVITY OF PLASMA

被引：8

作者：

PADRO, T ^{[1
]}

VANDENHOOGEN, CM ^{[1
]}

EMEIS, JJ ^{[1
]}

机构：

[1] TNO,IVVO,GAUBIUS LAB,POB 430,2300 AK LEIDEN,NETHERLANDS

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 1991年 / 51卷 / 07期

关键词：

ALPHA-2-ANTIPLASMIN; PLASMA; PLASMIN INHIBITION; RAT; TISSUES;

D O I：

10.3109/00365519109104570

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Plasmin inhibition by rat tissue extracts was compared with rat plasma plasmin inhibition. Nine different tissues were extracted with an acid acetate-buffer (lung, heart, brain, adrenal, aorta, skeletal muscle, spleen and liver) or with KSCN-buffer (kidney), and antiplasmin activity was evaluated by a spectrophotometric method. All tissue extracts inhibited plasmin dose-dependently; the amount of plasmin inhibited by a fixed amount of extract depended upon the tissue. In rat plasma, antiplasmin activity was acid-labile, but acid treatment did not affect the plasmin inhibitory effect of tissues extracts.

引用

页码：599 / 603

页数：5

共 17 条

[1]

ALBRECHTSEN OK, 1959, ACTA PHYSL SCAN S165, V47, P13

[2]

ASTRUP T, 1971, THROMBOSIS BLEEDING, P370

[3] IMPROVED MEDIUM FOR EXTRACTION OF PLASMINOGEN-ACTIVATOR FROM TISSUE [J].

CAMIOLO, SM ;

SIUTA, MR ;

MADEJA, JM .

PREPARATIVE BIOCHEMISTRY, 1982, 12 (04) :297-305

[4]

EMEIS JJ, 1989, BLOOD, V74, P233

[5]

FRIBERGER P, 1978, HAEMOSTASIS, V7, P138

[6]

Hegt V N, 1977, Thromb Res, V10, P121, DOI 10.1016/0049-3848(77)90085-8

[7] HISTOCHEMICAL STUDY OF AN INHIBITOR OF FIBRINOLYSIS IN HUMAN ARTERIAL-WALL [J].

HEGT, VN ;

BRAKMAN, P .

NATURE, 1974, 248 (5443) :75-76

[8]

KLUFT C, 1984, THROMB HAEMOSTASIS, V51, P297

[9]

KOK P, 1979, THROMB HAEMOSTASIS, V41, P718

[10] PHYSIOLOGICAL-ROLE OF ALPHA-2-PLASMIN INHIBITOR IN RATS [J].

KUMADA, T ;

ABIKO, Y .

THROMBOSIS RESEARCH, 1984, 36 (02) :153-163

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