PRODUCTION OF INTERLEUKIN-8 BY CULTURED SYNOVIAL-CELLS IN RESPONSE TO INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR

被引：3

作者：

HIROTA, K

AKAHOSHI, T

ENDO, H

KONDO, H

KASHIWAZAKI, S

机构：

[1] KITASATO UNIV,SCH MED,DEPT INTERNAL MED,1-15-1 KITASATO,SAGAMIHARA,KANAGAWA 228,JAPAN

[2] TOKYO WOMENS MED COLL,INST RHEUMATOL,SHINJUKU KU,TOKYO 162,JAPAN

来源：

RHEUMATOLOGY INTERNATIONAL | 1992年 / 12卷 / 01期

关键词：

INTERLEUKIN-8; SYNOVIAL CELLS; RHEUMATOID ARTHRITIS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Both interleukin 1-alpha (IL-1-alpha) and tumor necrosis factor-alpha (TNF-alpha) stimulated the production of interleukin 8 (IL-8) by synovial cells in time and dose dependent manners. Enhanced chemotactic activity of polymorphonuclear cells (PMN) in culture supernatants of synovial cells was neutralized with anti-IL-8 antibody, thus showing synovial cells to be capable of secreting IL-8 which may contribute to PMN accumulation in rheumatoid inflamed joints.

引用

收藏

页码：13 / 16

页数：4

相关论文

共 20 条

[1]

EFFECT OF ACTINOMYCIN D + CHLORAMPHENICOL ON PROTEIN SYNTHESIS IN CHICK FIBROBLASTS [J].

AMOS, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1964, 80 (02) :269-&

[2]

CACHECTIN TUMOR NECROSIS FACTOR STIMULATES COLLAGENASE AND PROSTAGLANDIN-E2 PRODUCTION BY HUMAN SYNOVIAL-CELLS AND DERMAL FIBROBLASTS [J].

DAYER, JM ;

BEUTLER, B ;

CERAMI, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 162 (06) :2163-2168

[3]

HUMAN RECOMBINANT INTERLEUKIN-1 STIMULATES COLLAGENASE AND PROSTAGLANDIN E-2 PRODUCTION BY HUMAN SYNOVIAL-CELLS [J].

DAYER, JM ;

DEROCHEMONTEIX, B ;

BURRUS, B ;

DEMCZUK, S ;

DINARELLO, CA .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (02) :645-648

[4]

PRODUCTION OF COLLAGENASE AND PROSTAGLANDINS BY ISOLATED ADHERENT RHEUMATOID SYNOVIAL CELLS [J].

DAYER, JM ;

KRANE, SM ;

RUSSELL, RGG ;

ROBINSON, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (03) :945-949

[5]

ENDO H, 1991, LYMPHOKINE CYTOK RES, V10, P245

[6]

FRUTANI Y, 1985, NUCLEIC ACIDS RES, V13, P5869

[7]

PRODUCTION AND CHARACTERIZATION OF RECOMBINANT HUMAN NEUTROPHIL CHEMOTACTIC FACTOR [J].

FURUTA, R ;

YAMAGISHI, J ;

KOTANI, H ;

SAKAMOTO, F ;

FUKUI, T ;

MATSUI, Y ;

SOHMURA, Y ;

YAMADA, M ;

YOSHIMURA, T ;

LARSEN, CG ;

OPPENHEIM, JJ ;

MATSUSHIMA, K .

JOURNAL OF BIOCHEMISTRY, 1989, 106 (03) :436-441

[8]

SYNOVIUM AS A SOURCE OF INTERLEUKIN 6 INVITRO - CONTRIBUTION TO LOCAL AND SYSTEMIC MANIFESTATIONS OF ARTHRITIS [J].

GUERNE, PA ;

ZURAW, BL ;

VAUGHAN, JH ;

CARSON, DA ;

LOTZ, M .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (02) :585-592

[9]

MECHANISMS OF DISEASE - RHEUMATOID-ARTHRITIS - PATHOPHYSIOLOGY AND IMPLICATIONS FOR THERAPY [J].

HARRIS, ED .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (18) :1277-1289

[10]

LARSEN CG, 1989, IMMUNOLOGY, V68, P31