HETEROGENEITY OF CD5 MEMBRANE EXPRESSION ON B-CHRONIC LYMPHOCYTIC-LEUKEMIA CELLS

被引：6

作者：

KAY, NE

PETERSON, L

机构：

[1] Department of Medicine, Section of Hematology/Oncology, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN

[2] Department of Pathology, Hennepin County Medical Center, Minneapolis, MN

[3] Virginia Piper Cancer Institute, Abbott Northwestern Hospital, Minneapolis, MN

来源：

LEUKEMIA & LYMPHOMA | 1991年 / 5卷 / 01期

关键词：

CD5; CLL CELLS;

D O I：

10.3109/10428199109068104

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The CD5 antigen has been used to characterize the typical B-chronic lymphocytic leukemia B cell. CD5 antigen while found on mature T cells is also frequently found on malignant clonal B cells in B-CLL. We have sequentially evaluated the presence of CD5 antigen on a group of B-CLL cells using flow cytometry. Purified peripheral blood B cells from B-CLL patients were studied for the presence of both CD19 and CD5. This approach insured that the presence of CD5 antigen was only assessed on CD19 positive B cells. Our data suggests that there is considerable heterogeneity for presentation of CD5 antigen in clonal B cells in this disease. We define 3 B cell groups based on the presentation of CD5; low CD5, intermediate CD5 and high CD5 antigen positive B cells. In addition sequential analysis over several months of study indicates that the CD5 antigen is consistently present on these clonal B cells. Low CD5 B cells appear to have an excess of kappa phenotype. In conclusion CD5 antigen may be considerably more heterogeneous on clonal CLL B cells than previously thought. This variable presentation of CD5 antigen on CLL B cell clones needs to be considered in the assessment and characterization of B-CLL. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：49 / 55

页数：7

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