TOTAL SYNTHESIS OF SIASTATIN-B AND ITS ENANTIOMER USING CARBOHYDRATE AS A CHIRAL EDUCT

被引：20

作者：

NISHIMURA, Y

WANG, WM

KUDO, T

机构：

[1] Institute of Microbial Chemistry, Shinagawa-ku, Tokyo 141

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1992年 / 65卷 / 04期

关键词：

D O I：

10.1246/bcsj.65.978

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective synthesis of siastatin B, an inhibitor of neuraminidase and its antipode from D-ribono-gamma-lactone has stereospecifically been achieved. The total synthesis elucidated the absolute configuration of siastatin B as (3S,4S,5R,6R)-6-acetamido-4,5-dihydroxy-3-piperidinecarboxylic acid.

引用

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页码：978 / 986

页数：9

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