ENHANCEMENT BY IL-1-BETA AND IFN-GAMMA OF PLATELET ACTIVATION - ADHESION TO LEUKOCYTES VIA GMP-140 PADGEM PROTEIN (CD62)

被引：46

作者：

TODOROKI, N

WATANABE, Y

AKAIKE, T

KATAGIRI, Y

TANOUE, K

YAMAZAKI, H

TSUJI, T

TOYOSHIMA, S

OSAWA, T

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,DIV CHEM TOXICOL & IMMUNOCHEM,7-3-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN

[2] TOKYO INST TECHNOL,FAC BIOSCI & BIOTECHNOL,DEPT BIOMOLEC ENGN,MIDORI KU,YOKOHAMA,KANAGAWA 227,JAPAN

[3] TOKYO METROPOLITAN INST MED SCI,DEPT CARDIOVASC RES,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 179卷 / 02期

关键词：

D O I：

10.1016/0006-291X(91)91881-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have examined the effect of inflammatory cytokines on the platelet activation. IL-1β and IFN-γ were found to enhance the adhesion of thrombin-treated platelets to monocytic leukemia cells (U937), when the adhesion was assayed by platelet-mediated cell agglutination. The agglutination was inhibited by a monoclonal anti-GMP140 antibody or EDTA, suggesting that the enhanced platelet adhesion to the leukemic cells was mediated by GMP140. In addition, these cytokines also increased the release of 5-HT from platelets in the presence of a low concentration of thrombin. These data suggest that platelet functions are regulated by the cytokines and that activated platelets participate in inflammatory process. © 1991.

引用

页码：756 / 761

页数：6

共 16 条

[1] REQUIREMENT FOR SIALIC-ACID ON NEUTROPHILS IN A GMP-140 (PADGEM) MEDIATED ADHESIVE INTERACTION WITH ACTIVATED PLATELETS [J].