DIFFERENCES BETWEEN BLASTIC CHRONIC MYELOID-LEUKEMIA AND PH-POSITIVE ACUTE-LEUKEMIA

被引：32

作者：

BERGER, R

机构：

[1] Institut de Génétique Moléculaire, Paris

来源：

LEUKEMIA & LYMPHOMA | 1993年 / 11卷

关键词：

DIFFERENCES; BLASTIC CML; PH+ALL;

D O I：

10.3109/10428199309047892

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic and molecular characteristics of chronic myeloid leukemia in blast crisis and Ph-positive acute leukemia are compared. The main differences relate to the presence of Ph-negative metaphases at diagnosis and the disappearance of Ph in complete remission in acute leukemia, and the localization of the chromosome breakpoints in the BCR gene, in the bcr segment in chronic leukemia and in the first intron of the BCR gene in 50% of acute leukemias. The profiles of these abnormalities, as well as the types of additional chromosome changes, are not sufficient to distinguish between the two disorders in every patient. The distinction between these two entities, which is possible in the majority of patients, will be improved by results of experimental work currently in progress in many laboratories.

引用

页码：235 / 237

页数：3

共 23 条

[1] Catovsky D., PhI-positive acute leukaemia and chronic granulocytic leukaemia: one or two disease?, Br. J. Haematol., 42, pp. 493-498, (1979)
[2] Gale R.P., Butturini A., Ph-chromosome positive acute leukemias and acute phase of CML: one or two diseases. Two, Leuk. Res., 14, pp. 295-297, (1990)
[3] Bernstein R., Cytogenetics of chronic myelogenous leukemia, Sem. Hematol., 25, pp. 20-34, (1988)
[4] Sandberg A.A., The Chromosomes in Human Cancer and Leukemia, pp. 427-520, (1990)
[5] Berger R., Chen S.J., Chen Z., Philadelphia-positive acute leukemia. Cytogenetic and molecular aspects, Cancer Gen. Cytogen., 44, pp. 143-152, (1990)
[6] Bernstein R., Gale R.P., Do chromosome abnormalities determine the type of acute leukemia that develops in CML?, Leukemia, 4, pp. 65-68, (1990)
[7] Maddox A.M., Keating M.J., Trujillo J., Cork A., Younes E., Ahearn M.J., Freireich E.J., Philadelphia chromosome-positive adult acute leukemia with monosomy of chromosome number seven: A subgroup with poor response to therapy, Leuk. Res., 7, pp. 509-522, (1983)
[8] Russo C., Carroll A., Kehler S., Borowitz M., Amylon M., Homans A., Kedar A., Shuster J., Land V., Crist W., Pullen J., Link M., Philadelphia chromosome and monosomy 7 in childhood acute lymphoblastic leukemia: A Pediatric Oncology Group Study, Blood, 77, pp. 1050-1056, (1991)
[9] Secker-Walker L.M., Cooke H.M.G., Browett P.J., Shippey C.A., Norton J.D., Coustan-Smith E., Hoff-Brand A.V., Variable Philadelphia breakpoints and potential lineage restriction of bcr rearrangement in acute lymphoblastic leukemia, Blood, 72, pp. 784-791, (1988)
[10] Abe R., Ishibashi Y., Kimura H., Uchida T., Karyone S., The significance of cytogenetic findings of erythroid colonies derived from a Ph+ ALL patient: Fundamental differences between Ph+ ALL and blastic phase CML, Cancer Gen. Cytogen., 18, pp. 49-54, (1985)

← 1 2 3 →