C-ERBB-2 GENE-PRODUCT ASSOCIATES WITH CATENINS IN HUMAN CANCER-CELLS

被引：147

作者：

OCHIAI, A ^{[1
]}

AKIMOTO, S ^{[1
]}

KANAI, Y ^{[1
]}

SHIBATA, T ^{[1
]}

OYAMA, T ^{[1
]}

HIROHASHI, S ^{[1
]}

机构：

[1] NATL CANC CTR,RES INST,DIV PATHOL,CHUO KU,TOKYO 104,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 205卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.2631

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphorylation of beta-catenin, an intracytoplasmic cadherin-binding protein, causes disruption of the cadherin-mediated cell adhesion system in cancer cells. A 185-kDa phosphorylated protein, identified as the c-erbB-2 gene product, was co-immunoprecipitated with the E-cadherin-catenin complex. Association of the c-erbB-2 gene product with the cadherin-catenin complex was proven to be mediated through beta-catenin and plakoglobin using an in vitro protein-protein precipitation system. These results indicate that the c-erbB-2 gene product associates with catenins and may regulate the cell adhesion and invasive growth of cancer. (C) 1994 Academic Press, Inc.

引用

页码：73 / 78

页数：6

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