THE ROLE OF PATHOLOGY IN RODENT EXPERIMENTAL GERONTOLOGY

被引：13

作者：

BRONSON, RT ^{[1
]}

LIPMAN, RD ^{[1
]}

机构：

[1] TUFTS UNIV,HUMAN NUTR RES CTR,711 WASHINGTON ST,BOSTON,MA 02111

来源：

AGING-CLINICAL AND EXPERIMENTAL RESEARCH | 1993年 / 5卷 / 04期

关键词：

AGING; LESIONS; MICE; PATHOLOGY; RATS;

D O I：

10.1007/BF03324169

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The distinction between aging and age-related disease is a blurred one at best. Pathologic lesions and diseases, while having obvious importance for the well-being of an individual, are not more indicative of aging than are silent or benign aging changes. All lesions are useful as biomarkers of aging. They are definable, and can be characterized in terms of their prevalence and severity in different species, genotypes, genders, and age groups. Some data from previous studies are presented as examples. Many lesions of aging are quite restricted, in terms of prevalence or severity, to specific genotypes, species or genders. Recognition of the very great diversity of lesion biomarkers between genotypes, genders and species should prevent investigators from extrapolating findings in one genotype-gender to any other.

引用

页码：253 / 257

页数：5

共 6 条

[1]

Bronson R.T., Rate of occurrence of lesions in 20 inbred and hybrid genotypes of rats and mice sacrificed at 6 month intervals during the first years of life, Genetic Effects of Aging, pp. 279-358, (1990)

[2]

Bronson R.T., Lipman R.D., Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice, Growth Dev. Aging, 55, pp. 169-184, (1991)

[3]

Yunis E.J., Watson A.L., Gelman R.S., Sylvia S.J., Bronson R.T., Dorf M.E., Traits that influence longevity in mice, Genetics, 108, pp. 999-1011, (1984)

[4]

Gelman R., Watson A., Bronson R.T., Yunis E.J., Murine chromosomal regions correlated with longevity, Genetics, 118, pp. 693-704, (1988)

[5]

Committee of Animal Models for Aging. Mammalian Models for Research on Aging, (1981)

[6]

Weindruch R., Walford R.L., The Retardation of Aging and Disease by Dietary Restriction, (1988)

← 1 →