GENERATION OF SUPEROXIDE ANION AND HYDROGEN-PEROXIDE INDUCED BY NIFURTIMOX IN TRYPANOSOMA-CRUZI

被引：126

作者：

DOCAMPO, R ^{[1
]}

STOPPANI, AOM ^{[1
]}

机构：

[1] UNIV BUENOS AIRES, FAC MED, INST QUIM BIOL, BUENOS AIRES 1121, ARGENTINA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1979年 / 197卷 / 01期

关键词：

D O I：

10.1016/0003-9861(79)90251-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Addition of nifurtimox (a nitrofuran derivative) to Trypanosoma cruzi culture (epimastigote) forms induced an increase in the respiratory rate and the release of H2O2 from the whole cells to the suspending medium. Growth-inhibiting concentrations of nifurtimox were able to stimulate O2{minus sign, dot below} production by the T. cruzi mitochondrial fraction supplemented with NADH (or succinate), and also to enhance the generation of O2{minus sign, dot below} by the microsomal fraction with NADPH as reductant. © 1979.

引用

页码：317 / 321

页数：5

共 29 条

[1] BIAGLOW JE, 1976, BIOCHEM PHARMACOL, V25, P393, DOI 10.1016/0006-2952(76)90339-7
[2] BIAGLOW JE, 1977, MOL PHARMACOL, V13, P269
[3] HYDROGEN-PEROXIDE GENERATION IN TRYPANOSOMA-CRUZI
BOVERIS, A
STOPPANI, AOM
[J]. EXPERIENTIA, 1977, 33 (10): : 1306 - 1308
[4] EVALUATION OF HORSERADISH PEROXIDASE-SCOPOLETIN METHOD FOR MEASUREMENT OF HYDROGEN-PEROXIDE FORMATION IN BIOLOGICAL-SYSTEMS
BOVERIS, A
MARTINO, E
STOPPANI, AOM
[J]. ANALYTICAL BIOCHEMISTRY, 1977, 80 (01) : 145 - 158
[5] EFFECT OF BETA-LAPACHONE ON SUPEROXIDE ANION AND HYDROGEN-PEROXIDE PRODUCTION IN TRYPANOSOMA-CRUZI
BOVERIS, A
DOCAMPO, R
TURRENS, JF
STOPPANI, AOM
[J]. BIOCHEMICAL JOURNAL, 1978, 175 (02) : 431 - 439
[6] SUPEROXIDE ANION PRODUCTION AND TRYPANOCIDAL ACTION OF NAPHTHOQUINONES ON TRYPANOSOMA-CRUZI
BOVERIS, A
STOPPANI, AOM
DOCAMPO, R
CRUZ, FS
[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1978, 61 (02): : 327 - 329
[7] LOCALIZATION OF PEROXIDASE-ACTIVITY IN TRYPANOSOMA-CRUZI MICROBODIES
DOCAMPO, R
DEBOISO, JF
BOVERIS, A
STOPPANI, AOM
[J]. EXPERIENTIA, 1976, 32 (08): : 972 - 975
[8] TRICARBOXYLIC-ACID CYCLE OPERATION AT KINETOPLAST-MITOCHONDRION COMPLEX OF TRYPANOSOMA-CRUZI
DOCAMPO, R
BOISO, JFD
STOPPANI, AOM
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 502 (03) : 466 - 476
[9] LIPID PEROXIDATION AND GENERATION OF FREE-RADICALS, SUPEROXIDE ANION, AND HYDROGEN-PEROXIDE IN BETA-LAPACHONE-TREATED TRYPANOSOMA-CRUZI EPIMASTIGOTES
DOCAMPO, R
CRUZ, FS
BOVERIS, A
MUNIZ, RPA
ESQUIVEL, DMS
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1978, 186 (02) : 292 - 297
[10] BIOLOGY OF OXYGEN RADICALS
FRIDOVICH, I
[J]. SCIENCE, 1978, 201 (4359) : 875 - 880

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