EFFECT OF STAUROSPORINE ON THE PHORBOL ESTER-INDUCED ACTIVATION OF THE NA+/H+ ANTIPORTER IN SMOOTH-MUSCLE CELLS

被引：3

作者：

BOSCOBOINIK, DO

HENSEY, CE

AZZI, A

机构：

[1] UNIV BERN, INST BIOCHEM & MOLEK BIOL, BUHLSTR 28, CH-3012 BERN, SWITZERLAND

[2] NATL UNIV IRELAND UNIV COLL DUBLIN, DEPT BIOCHEM, DUBLIN 4, IRELAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1052卷 / 03期

关键词：

(Rat aortic smooth muscle cell); Antiporter; Na[!sup]+[!/sup]/H[!sup]+[!/sup; Phorbol ester; Protein kinase C; Staurosporine;

D O I：

10.1016/0167-4889(90)90161-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evidence is presented suggesting that the Na+/H+ antiporter activity of aortic smooth muscle cells is stimulated by protein kinase C activation. However, once the transporter has been activated, inhibitors of protein kinase C are not effective, supporting a model in which the Na+/H+ antiporter conserves memory of its activation by protein kinase C. © 1990.

引用

页码：499 / 502

页数：4

共 29 条

[1]

BERK BC, 1987, J BIOL CHEM, V262, P5057

[2] PHORBOL ESTERS RAPIDLY STIMULATE AMILORIDE-SENSITIVE NA+/H+ EXCHANGE IN A HUMAN-LEUKEMIC CELL-LINE [J].