SUPPRESSION OF INVITRO IMMUNOGLOBULIN BIOSYNTHESIS IN BOVINE SPLEEN-CELLS BY BOVINE VIRAL DIARRHEA VIRUS

被引：25

作者：

ATLURU, D ^{[1
]}

NOTOWIDJOJO, W ^{[1
]}

JOHNSON, DW ^{[1
]}

MUSCOPLAT, CC ^{[1
]}

机构：

[1] UNIV MINNESOTA,COLL VET MED,DEPT LARGE ANIM CLIN SCI,ST PAUL,MN 55108

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1979年 / 13卷 / 03期

关键词：

D O I：

10.1016/0090-1229(79)90070-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Incubation of bovine splenic lymphoid cells with pokeweed mitogen (PWM) and bovine viral diarrhea (BVD) virus for 5 days caused a consistent, statistically significant decrease in plasma cell development (cells containing intracytoplasmic immunoglobulin) as well as IgG or IgM synthesis compared to cultures without BVD virus. Suppression of plasma cell development and immunoglobulin synthesis was not due to decreased cell viability in virus-infected cultures even though virus replication was evident in both PWM-stimulated as well as control cultures. Finally, it was shown that heat-inactivated BVD virus was not capable of suppressing either plasma cell development or immunoglobulin synthesis. Thus, these data support the hypothesis that BVD virus can alter B-cell responses, plasma cell development, and subsequent synthesis of IgG and IgM immunoglobulins. © 1979.

引用

页码：254 / 260

页数：7

共 24 条

[1] ATLURU D, AM J VET RES
[2] BLOOD DC, 1974, VETERINARY MEDICINE
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[4] CARBREY EA, 1971, P US ANIM HLTH ASS, V629
[5] DENT PB, 1968, JNCI-J NATL CANCER I, V41, P391
[6] DENT PB, 1965, P SOC EXP BIOL MED, V119, P869
[7] DENT PB, 1968, IMMUNOLOGIC DEFICIEN, V4
[8] JOHNSON DW, 1973, AM J VET RES, V34, P1139
[9] KAHRS RF, 1971, J AM VET MED ASS, V11, P1383
[10] LAMBERT G, 1973, J AM VET MED ASSOC, V163, P1189

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