INHALATIONAL ANESTHETICS STEREOCHEMISTRY - OPTICAL RESOLUTION OF HALOTHANE, ENFLURANE, AND ISOFLURANE

被引:59
作者
MEINWALD, J
THOMPSON, WR
PEARSON, DL
KONIG, WA
RUNGE, T
FRANCKE, W
机构
[1] PARK PLAZA HOSP,DEPT ANESTHESIOL,HOUSTON,TX 77004
[2] UNIV HAMBURG,INST ORGAN CHEM,W-2000 HAMBURG 13,GERMANY
关键词
D O I
10.1126/science.1846702
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Halothane (I), enflurane (II), and isoflurane (III), which are among the most important inhalation anesthetics, are currently administered as racemic mixtures. The pure enantiomers have not been described, and no analytical method for resolving the commercially available racemic mixtures has been reported. Complete optical resolution of (+/-)-I and (+/-)-III on per-n-pentylated alpha-cyclodextrin (Lipodex A) and of (+/-)-II and (+/-)-III on octakis(6-O-methyl-2,3-di-O-pentyl)-gamma-cyclodextrin capillary columns has been achieved, making rapid and convenient determination of enantiomeric ratios in samples of all three of these anesthetics possible.
引用
收藏
页码:560 / 561
页数:2
相关论文
共 17 条